GADD45A plays a protective role against temozolomide treatment in glioblastoma cells

@inproceedings{Wang2017GADD45APA,
  title={GADD45A plays a protective role against temozolomide treatment in glioblastoma cells},
  author={Hsiao-Han Wang and T L Chang and Wei-Chen Lin and Kuo-Chen Wei and Jyh-Wei Shin},
  booktitle={Scientific Reports},
  year={2017}
}
Glioblastoma multiforme (GBM) is one of the most aggressive cancers. Despite recent advances in multimodal therapies, high-grade glioma remains fatal. Temozolomide (TMZ) is an alkylating agent used worldwide for the clinical treatment of GBM; however, the innate and acquired resistance of GBM limits its application. Here, we found that TMZ inhibited the proliferation and induced the G2/M arrest of GBM cells. Therefore, we performed microarrays to identify the cell cycle- and apoptosis-related… CONTINUE READING