GADD45α Induction by Nickel Negatively Regulates JNKs/p38 Activation via Promoting PP2Cα Expression

@inproceedings{Yu2013GADD45IB,
  title={GADD45α Induction by Nickel Negatively Regulates JNKs/p38 Activation via Promoting PP2Cα Expression},
  author={Yonghui Yu and Jingxia Li and Yu Wan and Jianyi Lu and Jimin Gao and Chuanshu Huang},
  booktitle={PloS one},
  year={2013}
}
Growth arrest and DNA damage (GADD) 45α is a member of GADD inducible gene family, and is inducible in cell response to oxidative stress. GADD45α upregulation induces MKK4/JNK activation in some published experimental systems. However, we found here that the depletion of GADD45α (GADD45α-/-) in mouse embryonic fibroblasts (MEFs) resulted in an increase in… CONTINUE READING