GADD34–PP1c recruited by Smad7 dephosphorylates TGFβ type I receptor

@article{Shi2004GADD34PP1cRB,
  title={GADD34–PP1c recruited by Smad7 dephosphorylates TGFβ type I receptor},
  author={Weibin Shi and Chuanxi Sun and Bin He and Wencheng Xiong and Xingming Shi and Dachun Yao and Xu Cao},
  journal={The Journal of Cell Biology},
  year={2004},
  volume={164},
  pages={291 - 300}
}
The cascade of phosphorylation is a pivotal event in transforming growth factor beta (TGFbeta) signaling. Reversible phosphorylation regulates fundamental aspects of cell activity. TGFbeta-induced Smad7 binds to type I receptor (TGFbeta type I receptor; TbetaRI) functioning as a receptor kinase antagonist. We found Smad7 interacts with growth arrest and DNA… CONTINUE READING