GAD65 autoantibody epitopes in adult patients with latent autoimmune diabetes following GAD65 vaccination.

@article{Bekris2007GAD65AE,
  title={GAD65 autoantibody epitopes in adult patients with latent autoimmune diabetes following GAD65 vaccination.},
  author={Lynn M Bekris and Richard Alan Jensen and Eliza Lagerquist and Tyler R. Hall and C-D Agardh and Corrado Maria Cilio and Asa L Lethagen and {\AA}ke Lernmark and John A. Robertson and C S Hampe},
  journal={Diabetic medicine : a journal of the British Diabetic Association},
  year={2007},
  volume={24 5},
  pages={
          521-6
        }
}
AIMS Subcutaneous injection of recombinant human GAD65 (rhGAD65) in patients with latent autoimmune diabetes in adults (LADA) correlates with an increase in C-peptide levels. In this study we analysed the effect of rhGAD65 administration on the GAD65-specific autoimmune response. METHODS Longitudinal serum samples obtained from LADA patients (n = 47) who received 4, 20, 100 or 500 microg alum-formulated rhGAD65 or placebo by subcutaneous injection twice (4 weeks apart) were analysed for their… CONTINUE READING
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