GAD2 Alternative Transcripts in the Human Prefrontal Cortex, and in Schizophrenia and Affective Disorders

@inproceedings{Davis2016GAD2AT,
  title={GAD2 Alternative Transcripts in the Human Prefrontal Cortex, and in Schizophrenia and Affective Disorders},
  author={Kasey N. Davis and Ran Tao and Chao Li and Yuan Gao and Marjorie C Gondr{\'e}-Lewis and Barbara K. Lipska and Joo Heon Shin and Bin Xie and Tianzhang Ye and Daniel R. Weinberger and Joel E. Kleinman and Thomas M. Hyde and Consuelo Walss-Bass},
  booktitle={PloS one},
  year={2016}
}
Genetic variation and early adverse environmental events work together to increase risk for schizophrenia. γ-aminobutyric acid (GABA), the major inhibitory neurotransmitter in adult mammalian brain, plays a major role in normal brain development, and has been strongly implicated in the pathobiology of schizophrenia. GABA synthesis is controlled by two glutamic acid decarboxylase (GAD) genes, GAD1 and GAD2, both of which produce a number of alternative transcripts. Genetic variants in the GAD1… CONTINUE READING
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