GAD1 single nucleotide polymorphism is in linkage disequilibrium with a child bipolar I disorder phenotype.

  title={GAD1 single nucleotide polymorphism is in linkage disequilibrium with a child bipolar I disorder phenotype.},
  author={Barbara Geller and Rebecca Tillman and Kristine Bolhofner and Kathleen A Hennessy and Edwin H. Cook},
  journal={Journal of child and adolescent psychopharmacology},
  volume={18 1},
BACKGROUND Pediatric bipolar I disorder (BP-I) and childhood schizophrenia (SZ) share certain symptoms (e.g., psychosis, aggression/irritability [A/I]), and the psychotic and A/I features are treated with neuroleptics in both disorders. Thus, it is of interest to examine the association of GAD1 to child BP-I because of its recently reported association to childhood SZ. METHODS Child BP-I probands were obtained by consecutive new case ascertainment, and the phenotype was defined as current DSM… CONTINUE READING


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