GAD autoantibody affinity and epitope specificity identify distinct immunization profiles in children at risk for type 1 diabetes.

@article{Mayr2007GADAA,
  title={GAD autoantibody affinity and epitope specificity identify distinct immunization profiles in children at risk for type 1 diabetes.},
  author={Anja Mayr and Michael Schlosser and Natalie Grober and Heidrun Kenk and Anette-G. Ziegler and Ezio Bonifacio and Peter Achenbach},
  journal={Diabetes},
  year={2007},
  volume={56 6},
  pages={1527-33}
}
OBJECTIVE Autoantibodies to insulin and GAD are features of preclinical type 1 diabetes in children. For insulin autoantibodies, the antibody affinity and epitope specificity predict which children progress to diabetes. We asked whether autoantibodies to GAD (GADAs) are heterogeneous in affinity and epitope recognition and whether diabetes-related GADA are restricted to high-affinity responses. RESEARCH DESIGN AND METHODS GADA affinity was measured by competitive binding experiments with… CONTINUE READING
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Identification FIG

  • MH Butler, M Solimena, R JrDirkx, A Hayday, P De Camilli
  • (broken red line). GAD AUTOANTIBODY AFFINITY IN…
  • 2007

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