GAD-IgG-inducing CD4+Foxp3+Treg cells suppressing diabetes are involved in the increasing ratio of CD80+:CD86+ CELLS in NOD mice.


BACKGROUND Our previous studies have demonstrated that GAD-IgG-transduced splenocytes protect non-obese diabetic (NOD) mice from diabetes by in vitro-inducing CD4(+)Foxp3(+)Treg cells. However, the underlying mechanisms by which CD4(+)Foxp3(+)Treg cells suppress diabetes remain unclear. METHODS Seven-week-old female NOD mice were intravenously injected… (More)
DOI: 10.1016/j.arcmed.2007.11.007


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