GAD Antibody Positivity Predicts Type 2 Diabetes in an Adult Population

  title={GAD Antibody Positivity Predicts Type 2 Diabetes in an Adult Population},
  author={Virve M. Lundgren and Bo Isomaa and Valeriya Lyssenko and Esa Laurila and Pasi Korhonen and Leif Groop and Tiinamaija Tuomi},
OBJECTIVE To evaluate the significance of GAD antibodies (GADAs) and family history for type 1 diabetes (FH(T1)) or type 2 diabetes (FH(T2)) in nondiabetic subjects. RESEARCH DESIGN AND METHODS GADAs were analyzed in 4,976 nondiabetic relatives of type 2 diabetic patients or control subjects from Finland. Altogether, 289 (5.9%) were GADA(+)-a total of 253 GADA(+) and 2,511 GADA(-) subjects participated in repeated oral glucose tolerance tests during a median time of 8.1 years. The risk of… CONTINUE READING
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  • V Lyssenko, P Almgren, +10 authors T V.M. Tuomi
  • VOL. 59,
  • 2010
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