GABRG1 and GABRA2 variation associated with alcohol dependence in African Americans.

  title={GABRG1 and GABRA2 variation associated with alcohol dependence in African Americans.},
  author={Chupong Ittiwut and Bao-zhu Yang and Henry R. Kranzler and Raymond F. Anton and Rungnapa Hirunsatit and Roger D. Weiss and Jonathan Covault and Lindsay A. Farrer and Joel Gelernter},
  journal={Alcoholism, clinical and experimental research},
  volume={36 4},
BACKGROUND GABRG1 and GABRA2, genes that encode the γ1 and α2 subunits, respectively, of the GABA-A receptor, are located in a cluster on chromosome 4p. Association of alcohol dependence (AD) with markers located at the 3' region of GABRA2 has been replicated in several studies, but recent studies suggested the possibility that the signal may be attributable to the adjacent gene, GABRG1, located 90 kb distant in the 3' direction. Owing to strong linkage disequilibrium (LD) in European Americans… CONTINUE READING
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