GABRA2 Alleles Moderate the Subjective Effects of Alcohol, Which are Attenuated by Finasteride

  title={GABRA2 Alleles Moderate the Subjective Effects of Alcohol, Which are Attenuated by Finasteride},
  author={Amira Pierucci-Lagha and J. Covault and R. Feinn and M. Nellissery and C. Hern{\'a}ndez-{\'A}vila and C. Oncken and A. Morrow and H. Kranzler},
  • Amira Pierucci-Lagha, J. Covault, +5 authors H. Kranzler
  • Published 2005
  • Medicine
  • Neuropsychopharmacology
  • GABAA receptors are involved in the subjective effects of alcohol. Endogenous neuroactive steroids interact with GABAA receptors to mediate several behavioral effects of alcohol in rodents. Based on a haplotypic association of alcohol dependence with the gene encoding the GABAA receptor α-2 subunit (GABRA2), we examined whether GABRA2 alleles are associated with the subjective response to alcohol. We also examined whether finasteride (a 5-α steroid reductase inhibitor), which blocks the… CONTINUE READING
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