• DOI:10.1038/sj.npp.1300688
Corpus ID: 27119040

GABRA2 Alleles Moderate the Subjective Effects of Alcohol, Which are Attenuated by Finasteride

@article{PierucciLagha2005GABRA2AM,
  title={GABRA2 Alleles Moderate the Subjective Effects of Alcohol, Which are Attenuated by Finasteride},
  author={Amira Pierucci-Lagha and J. Covault and R. Feinn and M. Nellissery and C. Hern{\'a}ndez-{\'A}vila and C. Oncken and A. Morrow and H. Kranzler},
  journal={Neuropsychopharmacology},
  year={2005},
  volume={30},
  pages={1193-1203}
}

Amira Pierucci-Lagha, J. Covault, +5 authors H. Kranzler

Published 2005

Medicine

Neuropsychopharmacology

GABAA receptors are involved in the subjective effects of alcohol. Endogenous neuroactive steroids interact with GABAA receptors to mediate several behavioral effects of alcohol in rodents. Based on a haplotypic association of alcohol dependence with the gene encoding the GABAA receptor α-2 subunit (GABRA2), we examined whether GABRA2 alleles are associated with the subjective response to alcohol. We also examined whether finasteride (a 5-α steroid reductase inhibitor), which blocks the… CONTINUE READING

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