GABAergic modulation of lindane (gamma-hexachlorocyclohexane)-induced seizures.

  title={GABAergic modulation of lindane (gamma-hexachlorocyclohexane)-induced seizures.},
  author={Cristina Su{\~n}ol and Josep Maria Tusell and Emilio Gelp{\'i} and Eduard Rodr{\'i}guez-Farr{\'e}},
  journal={Toxicology and applied pharmacology},
  volume={100 1},
The main objective of this work was to study the role of the GABAergic system on the convulsions elicited by the organochlorine insecticide lindane. The concentration of lindane in rat brain at the onset of the first tonic convulsion was taken as the endpoint for the neurotoxic action of the insecticide administered by intravenous infusion. Pretreatment with the GABA agonists muscimol and progabide, the GABA uptake blocker SK&F 89976-A, the GABA transaminase inhibitor gamma-acetylenic GABA, and… CONTINUE READING