GABAergic modulation of DC stimulation-induced motor cortex excitability shifts in humans.

@article{Nitsche2004GABAergicMO,
  title={GABAergic modulation of DC stimulation-induced motor cortex excitability shifts in humans.},
  author={Michael A. Nitsche and David Liebetanz and Anett Schlitterlau and Undine Henschke and Kristina Fricke and Kai Frommann and Nicolas Lang and Stefan Henning and Walter Paulus and Frithjof Tergau},
  journal={The European journal of neuroscience},
  year={2004},
  volume={19 10},
  pages={2720-6}
}
Weak transcranial DC stimulation (tDCS) of the human motor cortex results in excitability shifts during and after the end of stimulation, which are most probably localized intracortically. Anodal stimulation enhances excitability, whereas cathodal stimulation reduces it. Although the after-effects of tDCS are NMDA receptor-dependent, nothing is known about the involvement of additional receptors. Here we show that pharmacological strengthening of GABAergic inhibition modulates selectively the… CONTINUE READING
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