GABAergic mechanism of propofol toxicity in immature neurons.

  title={GABAergic mechanism of propofol toxicity in immature neurons.},
  author={Sibel Kahraman and Susan L. Zup and Margaret M McCarthy and Gary Fiskum},
  journal={Journal of neurosurgical anesthesiology},
  volume={20 4},
Certain anesthetics exhibit neurotoxicity in the brains of immature but not mature animals. Gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter in the adult brain, is excitatory on immature neurons via its action at the GABAA receptor, due to a reversed transmembrane chloride gradient. GABAA receptor activation in immature neurons is sufficient to open L-type voltage-gated calcium channels. As propofol is a GABAA agonist, we hypothesized that it and more specific GABAA… CONTINUE READING