GABAergic inhibition shapes interictal dynamics in awake epileptic mice.

@article{Muldoon2015GABAergicIS,
  title={GABAergic inhibition shapes interictal dynamics in awake epileptic mice.},
  author={Sarah Muldoon and Vincent Villette and Thomas Tressard and Arnaud Malvache and Susanne Reichinnek and Fabrice Bartolomei and Rosa Cossart},
  journal={Brain : a journal of neurology},
  year={2015},
  volume={138 Pt 10},
  pages={
          2875-90
        }
}
Epilepsy is characterized by recurrent seizures and brief, synchronous bursts called interictal spikes that are present in-between seizures and observed as transient events in EEG signals. While GABAergic transmission is known to play an important role in shaping healthy brain activity, the role of inhibition in these pathological epileptic dynamics remains unclear. Examining the microcircuits that participate in interictal spikes is thus an important first step towards addressing this issue… CONTINUE READING

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