GABAergic inhibition of crayfish deep extensor abdominal muscle exhibits a steep dose-response relationship and a high degree of cooperativity

@article{Beckerath2004GABAergicIO,
  title={GABAergic inhibition of crayfish deep extensor abdominal muscle exhibits a steep dose-response relationship and a high degree of cooperativity},
  author={Nicolas von Beckerath and Helmuth Adelsberger and Franz Parzefall and Ch. Franke and Josef Dudel},
  journal={Pfl{\"u}gers Archiv},
  year={2004},
  volume={429},
  pages={781-788}
}
A patch-clamp study was done to characterize the recently found GABAergic (i.e. γ-aminobutyric acid) inhibitory synaptic channels of crayfish deep extensor abdominal muscle. Outside-out patches were rapidly activated by GABA to measure the dose/ response curves for the open probability of the channels, Po, and the rise time, tr, (time from Po=0.1 to Po=0.9). In some of the patches the GABA-activated currents decayed due to desensitization and such patches were not studied further. Rare channel… 
Characterization and molecular reaction scheme of a chloride channel expressed after axotomy in crayfish
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A molecular scheme for the reaction between γ-aminobutyric acid and the most abundant chloride channel on crayfish deep extensor abdominal muscle
TLDR
Simulations of the dose-responses and the open time distributions with this model led to a set of rate constants which generated relatively optimal fits, and indicated at least three open states.
Activation kinetics of Glutamate receptor channels from wild-type Drosophila muscle
TLDR
Outside-out patches from wild-type Drosophila larval muscle were exposed briefly to L-Glutamate (Glu) using a piezo-driven application system, showing evidence for a common kinetic mechanism of these channels.
Innervation pattern of the deep extensor abdominal muscle in the crayfish species Astacus astacus
TLDR
The deep extensor abdominal muscle consisting of one medial and two lateral muscle bundles together with the nerve innervating the muscles of crayfish species Astacus astacus, was prepared and the innervation pattern of the axons was determined.

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