GABAergic excitotoxicity injury of the immature hippocampal pyramidal neurons' exposure to isoflurane.

@article{Zhao2011GABAergicEI,
  title={GABAergic excitotoxicity injury of the immature hippocampal pyramidal neurons' exposure to isoflurane.},
  author={Yilin Zhao and Qiang Xiang and Qingyu Shi and Si Ying Li and L Tan and Jimmy Tanche Wang and Xin Jin and Ai-lin Luo},
  journal={Anesthesia and analgesia},
  year={2011},
  volume={113 5},
  pages={1152-60}
}
BACKGROUND Certain anesthetics exhibit neurotoxicity in the brains of immature but not mature animals. γ-Aminobutyric acid (GABA), the primary inhibitory neurotransmitter in the adult brain, is excitatory on immature neurons via its action at the GABAA receptor, depolarizing the membrane potential and inducing a cytosolic Ca2+ increase ([Ca2+]i), because of a reversed transmembrane chloride gradient. Recent experimental data from several rodent studies have demonstrated that exposure to… CONTINUE READING
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