GABAergic control of CA3-driven network events in the developing hippocampus.

@article{Sipil2007GABAergicCO,
  title={GABAergic control of CA3-driven network events in the developing hippocampus.},
  author={Sampsa T. Sipil{\"a} and Kai Kaila},
  journal={Results and problems in cell differentiation},
  year={2007},
  volume={44},
  pages={
          99-121
        }
}
Endogenous activity is a characteristic feature of developing neuronal networks. In the neonatal rat hippocampus, spontaneously occurring network events known as "Giant Depolarizing Potentials" (GDPs) are seen in vitro at a stage when GABAergic transmission is depolarizing. GDPs are triggered by the CA3 region and they are seen as brief recurrent events in field-potential recordings, paralleled by depolarization and spiking of pyramidal neurons. In the light of current data, GDPs are triggered… CONTINUE READING
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