GABAergic and developmental influences on homosynaptic LTD and depotentiation in rat hippocampus.

@article{Wagner1995GABAergicAD,
  title={GABAergic and developmental influences on homosynaptic LTD and depotentiation in rat hippocampus.},
  author={John J. Wagner and Bradley E. Alger},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1995},
  volume={15 2},
  pages={1577-86}
}
Low-frequency (1 Hz) stimulation (LFS) was used to elicit long-term depression (LTD) or depotentiation of excitatory transmission of the Schaffer collateral pathway in the CA1 region of the rat hippocampus. Both LTD and depotentiation were found to be homosynaptic and NMDA receptor (NMDAR) dependent. As NMDAR activation can be modulated by the inhibitory GABAergic system, we tested the hypothesis that GABA plays a role in regulating these phenomena. The GABAB antagonist CGP 35348 significantly… CONTINUE READING