GABAc receptors

  title={GABAc receptors},
  author={Joachim Bormann and Andreas Feigenspan},
  journal={Trends in Neurosciences},

The 'ABC' of GABA receptors.

  • J. Bormann
  • Biology
    Trends in pharmacological sciences
  • 2000

GABAC Receptors: A Molecular View

  • R. Enz
  • Biology, Chemistry
    Biological chemistry
  • 2001
This review summarizes recent data in view of the molecular structure of GABAC receptors and presents new insights into the biological function of this protein in the retina.

Unsaturated Analogues of the Neurotransmitter GABA: trans-4-Aminocrotonic, cis-4-Aminocrotonic and 4-Aminotetrolic Acids

  • G. Johnston
  • Biology, Chemistry
    Neurochemical Research
  • 2015
Findings indicate that GABA activates GABAA receptors in extended conformations and GABAC receptors in folded conformations, which are important for the molecular modelling of ionotropic GABA receptors and to the development of new agents acting selectively on these receptors.


Conformationally restricted analogues of GABA have been used to help identify three major GABA receptors, termed GABAA, GABAB and GABAC receptors.

GABA(A) and GABA(C) receptors have contrasting effects on excitability in superior colliculus.

The present study used immunocytochemistry to demonstrate the presence of functional GABA(C) receptors in rat SC at protein level and suggest a disinhibitory role of these receptors in SC neuronal circuitry.

GABA receptors of bipolar cells from the skate retina: actions of zinc on GABA-mediated membrane currents.

The enhancing effect of zinc is due primarily to its ability to increase the sensitivity of the GABAA receptor, which may reflect the presence of a unique subtype of GAB AA receptor on the bipolar and Müller cells of the skate retina.

Metabolomic Approaches to Defining the Role(s) of GABAρ Receptors in the Brain

A targeted pharmacological, NMR-based functional metabolomic approach in Guinea pig brain cortical tissue slices revealed classes of metabolic activity associated with GABAρ which are distinct from other GABA receptors.

GABAC receptors are expressed in GABAergic and non-GABAergic neurons of the rat superior colliculus and visual cortex

The results show that in the SGS primarily GABAergic neurons express GABAC receptors whereas the majority of tectothalamic calbindin neurons and intrinsically projecting parvalbumin neurons do not.

Taurine release modified by GABAergic agents in hippocampal slices from adult and developing mice

The potentiation of taurine release by agents acting on the three types of GABA receptors in both adult and developing hippocampus further indicates the involvement of transporters operating in an outward direction.