GABARAPs regulate PI4P-dependent autophagosome:lysosome fusion.

  title={GABARAPs regulate PI4P-dependent autophagosome:lysosome fusion.},
  author={Hanzhi Wang and Hui-qiao Sun and Xiaohui Zhu and Li Zhang and Joseph P Albanesi and Beth Levine and Helen Yin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={112 22},
The Atg8 autophagy proteins are essential for autophagosome biogenesis and maturation. The γ-aminobutyric acid receptor-associated protein (GABARAP) Atg8 family is much less understood than the LC3 Atg8 family, and the relationship between the GABARAPs' previously identified roles as modulators of transmembrane protein trafficking and autophagy is not known. Here we report that GABARAPs recruit palmitoylated PI4KIIα, a lipid kinase that generates phosphatidylinositol 4-phosphate (PI4P) and… CONTINUE READING
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