GABAC receptors in the vertebrate retina

  title={GABAC receptors in the vertebrate retina},
  author={Peter D. Lukasiewicz},
  journal={Molecular Neurobiology},
In the central nervous system (CNS), the inhibitory transmitter GABA interacts with three subtypes of GABA receptors, type A, type B, and type C. Historically, GABA receptors have been classified as either the inotropic GABAA receptors or the metabotropic GABAB receptors. Over the past 10 yr, studies have shown that a third class, called the GABAC receptor, also exists. GABAC receptors are found primarily in the vertebrate retina and to some extent in other parts of the CNS. Although GABAA and… 

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  • R. OlsenA. Tobin
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  • 1990
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    Proceedings of the National Academy of Sciences of the United States of America
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