GABAC receptors in the vertebrate retina

@article{Lukasiewicz2007GABACRI,
  title={GABAC receptors in the vertebrate retina},
  author={Peter D. Lukasiewicz},
  journal={Molecular Neurobiology},
  year={2007},
  volume={12},
  pages={181-194}
}
In the central nervous system (CNS), the inhibitory transmitter GABA interacts with three subtypes of GABA receptors, type A, type B, and type C. Historically, GABA receptors have been classified as either the inotropic GABAA receptors or the metabotropic GABAB receptors. Over the past 10 yr, studies have shown that a third class, called the GABAC receptor, also exists. GABAC receptors are found primarily in the vertebrate retina and to some extent in other parts of the CNS. Although GABAA and… 

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References

SHOWING 1-10 OF 91 REFERENCES

Pharmacology of GABA receptor CI− channels in rat retinal bipolar cells

TLDR
GABA gates bicuculline- and baclofen-insensitive GABA receptors in rod bipolar cells of the rat retina were activated selectively by the GABA analogue cis-4-aminocrotonic acid (CACA) and may be similar to those receptors termed GABAC receptors.

Novel GABA responses from rod- driven retinal horizontal cells

TLDR
A chloridemediated current response from isolated rod-driven horizontal cells (H4) of the white perch retina that has this novel pharmacology is described.

Preferential suppression of the ON pathway by GABAC receptors in the amphibian retina.

TLDR
Electrophysiological recordings from neurons in the amphibian intact retina and retinal slice preparations indicate that ganglion cells possess both GABAA and GABAC receptors, and pharmacology is indicative of the GABac receptor.

Expression of mammalian gamma-aminobutyric acid receptors with distinct pharmacology in Xenopus oocytes.

TLDR
Compared the electrical and pharmacological properties of GABA receptors expressed by poly(A)+ RNA isolated from mammalian brain and retina, these results suggest that mammalian retina contains RNAs encoding GABA receptors with distinct pharmacology.

Differential pharmacology of GABAA and GABAC receptors on rat retinal bipolar cells.

A novel GABA receptor on bipolar cell terminals in the tiger salamander retina

TLDR
GA receptors on bipolar terminals appear to be pharmacologically different from the GABA receptors found on ganglion cell dendrites, which is similar to the pharmacology reported for the rho 1 GABA receptor subunit that was isolated from retina and expressed in Xenopus oocytes.

Molecular biology of GABAA receptors

  • R. OlsenA. Tobin
  • Biology, Chemistry
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 1990
TLDR
Subpopulations of GABAA receptors with different cellular and regional locations show differential sensitivity to GABA, to modulators like steroids, to physiological regulation, to disease processes, and to pharmacological manipulation by drugs such as benzodiazepines.

Cloning of a gamma-aminobutyric acid type C receptor subunit in rat retina with a methionine residue critical for picrotoxinin channel block.

TLDR
Cloning of two rat GABA receptor subunits after their previously identified human homologues reveals the molecular mechanism underlying PTX blockade of GABA receptors but also the heteromeric nature of native receptors in the rat retina that underlie the PTX-resistant GABAC response.

Dopamine modulation of GABAC receptor function in an isolated retinal neuron.

TLDR
These findings provide the first evidence for dopamine modulation of GABA receptor function in the vertebrate nervous system and suggest that in the intact retina, dopamine may modulate GABA-mediated chemical coupling and autofeedback in horizontal cells.

Cloning of the gamma-aminobutyric acid (GABA) rho 1 cDNA: a GABA receptor subunit highly expressed in the retina.

  • G. CuttingL. Lu G. Uhl
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1991
TLDR
Features are consistent with the identification of a GABA subunit, GABA rho 1, with prominent retinal expression that increases the diversity and tissue specificity of this ligand-gated ion-channel receptor family.
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