GABAB receptors as a therapeutic strategy in substance use disorders: Focus on positive allosteric modulators

  title={GABAB receptors as a therapeutic strategy in substance use disorders: Focus on positive allosteric modulators},
  author={M. Filip and M. Frankowska and A. Sadakierska-Chudy and A. Suder and J. Cryan},
  • M. Filip, M. Frankowska, +2 authors J. Cryan
  • Published 2015
  • Psychology, Medicine
  • Neuropharmacology
  • γ-Aminobutyric acid B (GABAB) receptors and their ligands are postulated as potential therapeutic targets for the treatment of several brain disorders, including drug dependence. Over the past fifteen years positive allosteric modulators (PAMs) have emerged that enhance the effects of GABA at GABAB receptors and which may have therapeutic effects similar to those of agonists but with superior side-effect profiles. This review summarizes current preclinical evidence supporting a role of GABAB… CONTINUE READING
    67 Citations
    Targeting GABAB receptors for anti-abuse drug discovery
    • 22
    • Highly Influenced
    Designing modulators of 5-hydroxytryptamine signaling to treat abuse disorders
    • 1
    Potential of Cannabinoid Receptor Ligands as Treatment for Substance Use Disorders
    • 15


    GABAB receptors in addiction and its treatment.
    • 75
    Allosteric Modulators of GABAB Receptors: Mechanism of Action and Therapeutic Perspective
    • 66
    • Highly Influential
    • PDF
    Chemistry and pharmacology of GABAB receptor ligands.
    • W. Froestl
    • Chemistry, Medicine
    • Advances in pharmacology
    • 2010
    • 94
    • Highly Influential
    • PDF
    GABAB receptors in reward processes.
    • 95
    Evaluation of the anxiolytic-like profile of the GABAB receptor positive modulator CGP7930 in rodents
    • 66
    GABA(B) receptors in drug addiction.
    • 51
    • Highly Influential
    • PDF
    GABAB Receptor-Positive Modulators: Enhancement of GABAB Receptor Agonist Effects In Vivo
    • 26
    • Highly Influential
    • PDF
    GABAB receptors and depression. Current status.
    • 89
    Effects of GABAB receptor ligands in animal tests of depression and anxiety.
    • 94
    • Highly Influential
    • PDF