GABAB receptors as a therapeutic strategy in substance use disorders: Focus on positive allosteric modulators
@article{Filip2015GABABRA, title={GABAB receptors as a therapeutic strategy in substance use disorders: Focus on positive allosteric modulators}, author={M. Filip and M. Frankowska and A. Sadakierska-Chudy and A. Suder and J. Cryan}, journal={Neuropharmacology}, year={2015}, volume={88}, pages={36-47} }
γ-Aminobutyric acid B (GABAB) receptors and their ligands are postulated as potential therapeutic targets for the treatment of several brain disorders, including drug dependence. Over the past fifteen years positive allosteric modulators (PAMs) have emerged that enhance the effects of GABA at GABAB receptors and which may have therapeutic effects similar to those of agonists but with superior side-effect profiles. This review summarizes current preclinical evidence supporting a role of GABAB… CONTINUE READING
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References
SHOWING 1-10 OF 164 REFERENCES
Allosteric Modulators of GABAB Receptors: Mechanism of Action and Therapeutic Perspective
- Biology, Medicine
- Current neuropharmacology
- 2007
- 66
- Highly Influential
- PDF
Chemistry and pharmacology of GABAB receptor ligands.
- Chemistry, Medicine
- Advances in pharmacology
- 2010
- 94
- Highly Influential
- PDF
The GABAB Receptor-Positive Modulator GS39783 and the GABAB Receptor Agonist Baclofen Attenuate the Reward-Facilitating Effects of Cocaine: Intracranial Self-Stimulation Studies in the Rat
- Psychology, Medicine
- Neuropsychopharmacology
- 2005
- 98
- PDF
Evaluation of the anxiolytic-like profile of the GABAB receptor positive modulator CGP7930 in rodents
- Psychology, Medicine
- Neuropharmacology
- 2008
- 66
GABA(B) receptors in drug addiction.
- Psychology, Medicine
- Pharmacological reports : PR
- 2008
- 51
- Highly Influential
- PDF
GABAB Receptor-Positive Modulators: Enhancement of GABAB Receptor Agonist Effects In Vivo
- Chemistry, Medicine
- Journal of Pharmacology and Experimental Therapeutics
- 2010
- 26
- Highly Influential
- PDF
Effects of GABAB receptor ligands in animal tests of depression and anxiety.
- Chemistry, Medicine
- Pharmacological reports : PR
- 2007
- 94
- Highly Influential
- PDF