GABAB receptors as a therapeutic strategy in substance use disorders: focus on positive allosteric modulators.

@article{Filip2015GABABRA,
  title={GABAB receptors as a therapeutic strategy in substance use disorders: focus on positive allosteric modulators.},
  author={Małgorzata Filip and Małgorzata Frankowska and Anna Sadakierska-Chudy and Agata Suder and Lukasz Szumiec and Paweł Mierzejewski and Przemysław Bieńkowski and Edmund Przegaliński and John F Cryan},
  journal={Neuropharmacology},
  year={2015},
  volume={88},
  pages={36-47}
}
γ-Aminobutyric acid B (GABAB) receptors and their ligands are postulated as potential therapeutic targets for the treatment of several brain disorders, including drug dependence. Over the past fifteen years positive allosteric modulators (PAMs) have emerged that enhance the effects of GABA at GABAB receptors and which may have therapeutic effects similar to those of agonists but with superior side-effect profiles. This review summarizes current preclinical evidence supporting a role of GABAB… CONTINUE READING
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