• DOI:10.1016/j.neuropharm.2014.06.016
Corpus ID: 207229988

GABAB receptors as a therapeutic strategy in substance use disorders: Focus on positive allosteric modulators

@article{Filip2015GABABRA,
  title={GABAB receptors as a therapeutic strategy in substance use disorders: Focus on positive allosteric modulators},
  author={M. Filip and M. Frankowska and A. Sadakierska-Chudy and A. Suder and J. Cryan},
  journal={Neuropharmacology},
  year={2015},
  volume={88},
  pages={36-47}
}

M. Filip, M. Frankowska, +2 authors J. Cryan

Published 2015

Psychology, Medicine

Neuropharmacology

γ-Aminobutyric acid B (GABAB) receptors and their ligands are postulated as potential therapeutic targets for the treatment of several brain disorders, including drug dependence. Over the past fifteen years positive allosteric modulators (PAMs) have emerged that enhance the effects of GABA at GABAB receptors and which may have therapeutic effects similar to those of agonists but with superior side-effect profiles. This review summarizes current preclinical evidence supporting a role of GABAB… CONTINUE READING

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