GABAB receptors and glucose homeostasis: evaluation in GABAB receptor knockout mice.

@article{Bonaventura2008GABABRA,
  title={GABAB receptors and glucose homeostasis: evaluation in GABAB receptor knockout mice.},
  author={Mar{\'i}a Marta Bonaventura and Paolo N. Catalano and Astrid Chamson-Reig and Edith Juliana Arany and David Hill and Bernhard Bettler and Flavia Saravia and Carlos Libertun and Victoria A Lux-Lantos},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2008},
  volume={294 1},
  pages={
          E157-67
        }
}
GABA has been proposed to inhibit insulin secretion through GABAB receptors (GABABRs) in pancreatic beta-cells. We investigated whether GABABRs participated in the regulation of glucose homeostasis in vivo. The animals used in this study were adult male and female BALB/C mice, mice deficient in the GABAB1 subunit of the GABABR (GABAB(-/-)), and wild types (WT). Blood glucose was measured under fasting/fed conditions and in glucose tolerance tests (GTTs) with a Lifescan Glucose meter, and serum… 
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Sex differences in insulin resistance in GABAB1 knockout mice.
Effects of GABAB receptor agonists and antagonists on glycemia regulation in mice.
Postnatal development of the endocrine pancreas in mice lacking functional GABAB receptors.
TLDR
It is demonstrated that several islet parameters are altered in GABAB1KO mice, further pinpointing the importance of GABABRs in islet physiology.
Protein Restriction during Early Life in Rats Alters Pancreatic GABAA Receptor Subunit Expression and Glucagon Secretion in Adulthood
GABA Type B Receptor Signaling in Proopiomelanocortin Neurons Protects Against Obesity, Insulin Resistance, and Hypothalamic Inflammation in Male Mice on a High-Fat Diet
TLDR
The deletion of GABAB receptors in POMC neurons in the male mice on a high-fat diet results in obesity, insulin resistance, and hypothalamic inflammation, and the decreased P OMC expression in the obese KO mice suggests that the regulation of PomC expression through GABAB receptor is essential for proper energy balance.
Effect of GABA Receptor Agonists or Antagonists Injected Spinally on the Blood Glucose Level in Mice
TLDR
The results suggest that GABAB receptors located in the spinal cord play important roles for the elevation of the blood glucose level and spinally located PTX-sensitive G-proteins appear to be involved in hyperglycemic effect induced by baclofen.
Metabolomic Analysis of Plasma from GABAB(1) Knock-Out Mice Reveals Decreased Levels of Elaidic Trans-Fatty Acid
TLDR
The metabolomic analysis highlighted differences between the three genotypes of GABAB(1) KO mice and identified some metabolites less abundant in KO mice, namely elaidic acid and other fatty acids, and chiro-inositol.
Pancreatic GABA and Serotonin Actions in the Pancreas and Fetal Programming of Metabolism
TLDR
During pregnancies associated with suboptimal fetal growth, long-term changes to β-cell GABA receptor subtype expression can persist in the offspring into adulthood, compromising normal glucose homeostasis and contributing to the increased risk of metabolic disease.
The Potential Role of Pancreatic γ-Aminobutyric Acid (GABA) in Diabetes Mellitus: A Critical Reappraisal
TLDR
Pancreatic GABA improves islet cell function, glucose homeostasis, and autoimmunity in DM and represents a new therapeutic modality for both T1DM and T2DM.
GABAB Receptor Chemistry and Pharmacology: Agonists, Antagonists, and Allosteric Modulators.
TLDR
Lioresal® (Baclofen; β-(4-chlorophenyl)-γ-aminobutyric acid) is the only FDA-approved drug that selectively targets GABAB receptors in clinical use; undesirable side effects, such as sedation, muscle weakness, fatigue, cognitive deficits, seizures, tolerance and potential for abuse, limit their therapeutic use.
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