GABAB receptor promotes its own surface expression by recruiting a Rap1-dependent signaling cascade.

Abstract

G-protein-coupled receptors (GPCRs) are key players in cell signaling, and their cell surface expression is tightly regulated. For many GPCRs such as β2-AR (β2-adrenergic receptor), receptor activation leads to downregulation of receptor surface expression, a phenomenon that has been extensively characterized. By contrast, some other GPCRs, such as GABA(B… (More)
DOI: 10.1242/jcs.167056

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