GABAB receptor-mediated presynaptic potentiation of ATP ionotropic receptors in rat midbrain synaptosomes.

@article{GmezVillafuertes2003GABABRP,
  title={GABAB receptor-mediated presynaptic potentiation of ATP ionotropic receptors in rat midbrain synaptosomes.},
  author={Rosa G{\'o}mez-Villafuertes and Jes{\'u}s Pintor and Javier Gualix and M Teresa Miras-Portugal},
  journal={Neuropharmacology},
  year={2003},
  volume={44 3},
  pages={311-23}
}
Nucleotides can activate ionotropic P2X receptors that induce calcium-responses in rat midbrain synaptosomes. In this report, we show that ATP elicits Ca(2+) responses producing a monophasic dose-response curve with an EC(50) value of 24.24+/-1.42 micro M. In the presence of gamma-aminobutyric acid (GABA), the ATP dose-response curve becomes biphasic with… CONTINUE READING