GABAB-receptor-mediated actions of baclofen in rat isolated neocortical slice preparations: antagonism by phosphono-analogues of GABA.

Abstract

Baclofen, 3-amino-propylphosphonic acid (3-APPA), and beta-phenyl-GABA (BPG), each reduced the frequency of spontaneous paroxysmal discharges in rat neocortical slices maintained in Mg2+-free medium, reversibly antagonised by phaclofen and 4-amino-butylphosphonic acid (4-ABPA). At lower concentrations, not influencing the discharges, both 3-APPA and BPG… (More)

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@article{Kerr1989GABABreceptormediatedAO, title={GABAB-receptor-mediated actions of baclofen in rat isolated neocortical slice preparations: antagonism by phosphono-analogues of GABA.}, author={David I B Kerr and Jennifer Ong and Graham A. R. Johnston and R. H. Prager}, journal={Brain research}, year={1989}, volume={480 1-2}, pages={312-6} }