GABAB receptor dependent modulation of sharp wave-ripple complexes in the rat hippocampus in vitro.

@article{Hollnagel2014GABABRD,
  title={GABAB receptor dependent modulation of sharp wave-ripple complexes in the rat hippocampus in vitro.},
  author={Jan Oliver Hollnagel and Anna Maslarova and Rizwan ul Haq and Uwe F Heinemann},
  journal={Neuroscience letters},
  year={2014},
  volume={574},
  pages={15-20}
}
Sharp wave-ripple complexes (SPW-R) are observed in vivo during resting immobility, consummatory behavior and during slow wave sleep, and they have been proposed to support memory consolidation. It has been suggested that GABAergic cells play important roles in controlling incidence of sharp waves and of ripple frequency. We report here that the GABAB agonist baclofen reversibly suppresses SPW-R activity in rat hippocampal slices, presumably affecting the strength of neuronal coupling in the… CONTINUE READING