GABAB receptor antagonist SGS742 improves spatial memory and reduces protein binding to the cAMP response element (CRE) in the hippocampus.

@article{Helm2005GABABRA,
  title={GABAB receptor antagonist SGS742 improves spatial memory and reduces protein binding to the cAMP response element (CRE) in the hippocampus.},
  author={Katherine A. Helm and Rebecca P. Haberman and Shannon L. Dean and Eileen C Hoyt and Thorsten Melcher and Pauline Kay Lund and Michela Gallagher},
  journal={Neuropharmacology},
  year={2005},
  volume={48 7},
  pages={956-64}
}
Memory storage in the brain requires protein synthesis initiated through signaling pathways that control transcription. Such mechanisms are under active investigation for therapies in disorders involving cognitive dysfunction. Long-term memory can be improved by inhibiting activation or reducing expression of transcription factors such as ATF4/CREB2 and some C/EBP family members which appear to serve as memory suppressors. Here, we provide evidence that GABAB receptor antagonists may enhance… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 43 extracted citations

Low Cerebral Exposure Cannot Hinder the Neuroprotective Effects of Panax Notoginsenosides.

Drug metabolism and disposition: the biological fate of chemicals • 2018
View 2 Excerpts

Similar Papers

Loading similar papers…