GABAB receptor agonists reduce operant ethanol self-administration and enhance ethanol sedation in C57BL/6J mice

@article{Besheer2003GABABRA,
  title={GABAB receptor agonists reduce operant ethanol self-administration and enhance ethanol sedation in C57BL/6J mice},
  author={Joyce Besheer and Veronique Lepoutre and Clyde W Hodge},
  journal={Psychopharmacology},
  year={2003},
  volume={174},
  pages={358-366}
}
RationaleA growing number of studies suggest that γ-aminobutyric acid type-B (GABAB) receptor agonists reduce alcohol use and craving.ObjectivesThis study was designed to further clarify behavioral mechanism(s) by which GABAB agonists may decrease alcohol reinforcement.MethodsMale C57BL/6 J mice were trained to lever press on a concurrent schedule of ethanol (10% v/v) and water reinforcement during 16-h overnight sessions. Effects of the GABAB agonist baclofen (0–17 mg/kg, IP) or SKF 97541 (0–1… CONTINUE READING

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 14 CITATIONS

Targeting GABAB receptors for anti-abuse drug discovery.

  • Expert opinion on drug discovery
  • 2014
VIEW 2 EXCERPTS
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 45 REFERENCES

Benzodiazepine-GABA modulation of concurrent ethanol and sucrose reinforcement in the rat.

  • Experimental and clinical psychopharmacology
  • 1997
VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL

Baclofen and ethanol ingestion: a case report.

  • The Journal of emergency medicine
  • 1999
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

Suppression of ethanol-induced locomotor stimulation by GABA-like drugs

  • Naunyn-Schmiedeberg's Archives of Pharmacology
  • 1976
VIEW 2 EXCERPTS
HIGHLY INFLUENTIAL