GABAB receptor agonist baclofen improves methamphetamine-induced cognitive deficit in mice.

@article{Arai2009GABABRA,
  title={GABAB receptor agonist baclofen improves methamphetamine-induced cognitive deficit in mice.},
  author={Sawako Arai and Kazuhiro Takuma and Hiroyuki Mizoguchi and Daisuke Ibi and Taku Nagai and Hiroyuki Kamei and Hyoung-Chun Kim and Kiyofumi Yamada},
  journal={European journal of pharmacology},
  year={2009},
  volume={602 1},
  pages={101-4}
}
In this study, we investigated the effects of GABA(A) and GABA(B) receptor agonists on the methamphetamine-induced impairment of recognition memory in mice. Repeated treatment with methamphetamine at a dose of 1 mg/kg for 7 days induced an impairment of recognition memory. Baclofen, a GABA(B) receptor agonist, ameliorated the repeated methamphetamine-induced cognitive impairment, although gaboxadol, a GABA(A) receptor agonist, had no significant effect. GABA(B) receptors may constitute a… CONTINUE READING