GABAA receptors mediate inhibition of T cell responses

@article{Tian1999GABAARM,
  title={GABAA receptors mediate inhibition of T cell responses},
  author={Jide Tian and Cindy Chau and Tim G. Hales and Daniel L. Kaufman},
  journal={Journal of Neuroimmunology},
  year={1999},
  volume={96},
  pages={21-28}
}
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TLDR
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GABAergic signaling by cells of the immune system: more the rule than the exception.
TLDR
The data raised the assumption of conserved GABA signaling in a broad range of mammalian cells and diversification of function in the immune system and, as an interspecies signaling molecule in host-microbe interactions.
GABAA‐receptor expression in glioma cells is triggered by contact with neuronal cells
TLDR
It is shown that contact with neurons induces the expression of functional GABAA‐receptors, and with this form of interaction, neurons can influence tumour behaviour in the brain.
γ-Aninobutyric acid (GABA) suppresses antigen-specific immune responses in ovalbumin γ(OVA)-immunized BALB/c mice
TLDR
The results suggest that the suppressive effect of GABA on Ag-specific immune responses contributes to the reduction of antigen-presenting function on CD11c+ dendritic cells.
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