GABAA receptors mediate inhibition of T cell responses

@article{Tian1999GABAARM,
  title={GABAA receptors mediate inhibition of T cell responses},
  author={J. Tian and C. Chau and T. Hales and D. Kaufman},
  journal={Journal of Neuroimmunology},
  year={1999},
  volume={96},
  pages={21-28}
}
We describe the presence of functional GABA(A) receptors on T cells. GABA inhibited anti-CD3 and antigen-specific T cell proliferation in vitro in a dose-dependent manner that was 1) mimicked by the GABA(A) receptor agonist muscimol (but not the GABA(B) receptor agonist baclofen), 2) blocked by GABA(A) receptor antagonists and a GABA(A) receptor Cl- channel blocker (picrotoxin) and 3) enhanced by pentobarbital. These data suggest that GABA(A) receptors mediate this immune inhibition and that… Expand
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References

SHOWING 1-10 OF 34 REFERENCES
GABA modulates cytotoxicity of immunocompetent cells expressing GABAA receptor subunits.
TLDR
Gamma-aminobutyric acid effects seemed to be specific since they were partially mimicked by linear but not ramified GABA analogues, suggesting that under yet to be defined circumstances, GABA may affect T cell functions. Expand
GABAA receptor channels.
This chapter discusses the gamma-aminobutyric acid (GABA) receptor channels, which are the most abundant inhibitory neurotransmitter in the CNS. Following release from presynaptic vesicles, GABAExpand
Recruitment of functional GABAA receptors to postsynaptic domains by insulin
Modification of synaptic strength in the mammalian central nervous system (CNS) occurs at both pre- and postsynaptic sites,. However, because postsynaptic receptors are likely to be saturated byExpand
GABAB receptor pharmacology.
  • N. Bowery
  • Medicine
  • Annual review of pharmacology and toxicology
  • 1993
TLDR
The discovery that GABAB antagonism can suppress absence seizures in rats has provided an important therapeutic target and the emergence of brain-penetrating GABAB antagonists being discovered makes future studies an exciting prospect. Expand
Molecular biology of GABAA receptors
  • R. Olsen, A. Tobin
  • Biology, Medicine
  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 1990
TLDR
Subpopulations of GABAA receptors with different cellular and regional locations show differential sensitivity to GABA, to modulators like steroids, to physiological regulation, to disease processes, and to pharmacological manipulation by drugs such as benzodiazepines. Expand
In vitro inhibition of cellular immune responses by benzodiazepines and PK 11195. Effects on mitogen- and alloantigen-driven lymphocyte proliferation and on IL-1, IL-2 synthesis and IL-2 receptor expression.
TLDR
The most susceptible stage of mitogen-triggered T and B lymphocyte proliferation was found to be at incipience, and Cytotoxicity could not be made responsible for drug effects. Expand
Modulation of T lymphocyte function by neuropeptides. Evidence for their role as local immunoregulatory elements.
TLDR
It was concluded that the three study neuropeptides, over a broad range of concentrations, have profound stimulatory (and occasionally inhibitory) effects upon the function of a cloned T lymphocyte hybrid cell responding to specific Ag and that these events may reflect those of Ag-driven mucosal T lymphocytes exposed to neuropePTides in vivo. Expand
Local and diffuse synaptic actions of GABA in the hippocampus
TLDR
The inhibition of GABA uptake greatly enhanced both the presynaptic action of GABA and the slow GABAB-mediated inhibitory postsynaptic current, and uptake mechanisms restrict the spatial range of both point-to-point synaptic transmission mediated by GABA and its action at a distance. Expand
Bridging the cleft at GABA synapses in the brain
TLDR
Recent findings have started to unravel the operation of central GABA synapses where inhibitory events appear to result from the synchronous opening of only tens of GABAA receptors activated by a saturating concentration of GABA. Expand
Peripheral-type benzodiazepine receptors.
TLDR
The peripheral-type benzodiazepine receptor (PBR) seems at best only distantly related to CBRs, and recent cDNA cloning of a PBR component, the isoquinoline binding protein (IBP), shows no apparent sequence homology with any GABAA receptor subunits known to comprise central benzod GABA receptor subtypes. Expand
...
1
2
3
4
...