GABAA receptors are located in cholinergic terminals in the nucleus pontis oralis of the rat: Implications for REM sleep control

  title={GABAA receptors are located in cholinergic terminals in the nucleus pontis oralis of the rat: Implications for REM sleep control},
  author={C. -L Liang and Gerald A. Marks},
  journal={Brain Research},
Whole-Brain Neural Connectivity to Lateral Pontine Tegmentum GABAergic Neurons in Mice
A structural framework is provided to understand the underlying neural mechanisms of rapid eye movement sleep behavior disorder and disorders of saccades by mapping monosynaptic inputs and axonal projections of LPT GABAergic neurons in mice.
GABAA receptors in the basal forebrain mediates emergence from propofol anaesthesia in rats.
The basal fore brain is involved in modulating frontal cortex delta activity and emergence from propofol anaesthesia, and the GABAA receptors in the basal forebrain are involved in regulating emergence propofl anaesthesia.
Stereological estimations and neurochemical characterization of neurons expressing GABAA and GABAB receptors in the rat pedunculopontine and laterodorsal tegmental nuclei
The heterogeneous distribution of GABAAR and GABABR among non-cholinergic cells in PPN and LDT may give rise to physiological differences within each neurochemical subpopulation.
CeA-NPO circuits and REM sleep dysfunction in drug-refractory epilepsy
Effect of sedative-hypnotics, anesthetics and analgesics on sleep architecture in obstructive sleep apnea
This article critically reviewed the literature relevant to preoperative screening for OSA, prevalence of OSA in surgical populations and changes in postoperative sleep architecture relevant to OSA patients and addressed three questions in regard to the effects of sedative-hypnotics, anesthetics and analgesics on sleep architecture.
Cholinergic system neurochemistry toward therapeutic perspectives
Some selected concepts are mentioned as illustrative examples to put a spot light on the cholinergic system from both functional and therapeutical viewpoints.
Theory of Mind: Towards an Evolutionary Theory
Tonic immobility and immobilization stress are shown to facilitate eye-contact, gaze-following, and intentional attributions, which make them prime candidates in the search for the origin of theory of mind.
Bienzymatic Acetylcholinesterase and Choline Oxidase Immobilized Biosensor Based on a Phenyl Carboxylic Acid-Grafted Multiwalled Carbon Nanotube
Bienzymatic acetylcholinesterase (AChE) and choline oxidase (ChOx) immobilized biosensor based on a phenyl carboxylic acid-grafted multiwalled carbon nanotube (MWNT) modified glass carbon electrode
Enzymes as Diagnostic Tools
Administration of Alphas1-Casein Hydrolysate Increases Sleep and Modulates GABAA Receptor Subunit Expression
The results suggest αS1-CH, through GABAA receptor modulation, might be useful for treating sleep disorders.


GABAA Receptors in the Pontine Reticular Formation of C57BL/6J Mouse Modulate Neurochemical, Electrographic, and Behavioral Phenotypes of Wakefulness
The conclusion that GABAA receptors in the PnO promote wakefulness is supported and increasing GABAergic transmission in thePnO may be one mechanism underlying the phenomenon of paradoxical behavioral activation by some benzodiazepines is suggested.
GABAA receptors inhibit acetylcholine release in cat pontine reticular formation: implications for REM sleep regulation.
The finding that A Ch release in the PRF is modulated by GABAA receptors is consistent with the interpretation that inhibition of GABAergic transmission in thePRF contributes to the generation of REM sleep, in part, by increasing pontine ACh release.
Muscarinic and PACAP receptor interactions at pontine level in the rat: significance for REM sleep regulation
Recording sleep–wake cycles in freely moving rats showed that interactions between muscarinic and PACAP receptors do exist within the PnO and play a role in the local mechanisms of REM sleep control in the rat.
GABAergic regulation of REM sleep in reticularis pontis oralis and caudalis in rats.
The results indicate that GABA in RPO/RPC is involved in the regulation of REM and suggest site-specific differences in this regulation.
State-dependent release of acetylcholine in rat thalamus measured by in vivo microdialysis
In vivo microdialysis was used to monitor acetylcholine (ACh) release across behavioral state in the rat thalamus, demonstrating that mesopontine cholinergic neurons are active during both wake and REM sleep.
Endogenous GABA Levels in the Pontine Reticular Formation Are Greater during Wakefulness than during Rapid Eye Movement Sleep
The inverse relationship between changes in PRF levels of GABA and ACh during REM sleep indicates that low GABAergic tone combined with high cholinergic tone in the PRF contributes to the generation of REM sleep.