GABAA receptor subtype selectivity underlying selective anxiolytic effect of baicalin

@article{Wang2008GABAARS,
  title={GABAA receptor subtype selectivity underlying selective anxiolytic effect of baicalin},
  author={F. Wang and Z. Xu and Lihuan Ren and S. Tsang and H. Xue},
  journal={Neuropharmacology},
  year={2008},
  volume={55},
  pages={1231-1237}
}
Baicalin, a naturally occurring flavonoid, was previously reported to induce anxiolytic-like effect devoid of sedation and myorelaxation in mice, acting through type A gamma-aminobutyric acid (GABA(A)) receptor benzodiazepine (BZ) site. The present study further expanded the behavioral pharmacology profile of baicalin and subtype selectivity was explored as a possible mechanism underlying its in vivo effects on mice. Baicalin was characterized using convulsion, memory, and motor function… Expand
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