GABAA-receptor modification in taurine transporter knockout mice causes striatal disinhibition.

@article{Sergeeva2007GABAAreceptorMI,
  title={GABAA-receptor modification in taurine transporter knockout mice causes striatal disinhibition.},
  author={Olga A. Sergeeva and Wiebke Fleischer and Aisa N. Chepkova and Ulrich Warskulat and Dieter H{\"a}ussinger and Mario Siebler and Helmut L. Haas},
  journal={The Journal of physiology},
  year={2007},
  volume={585 Pt 2},
  pages={539-48}
}
The Striatum is involved in the regulation of movements and motor skills. We have shown previously, that the osmolyte and neuromodulator taurine plays a role in striatal plasticity. We demonstrate now that hereditary taurine deficiency in taurine-transporter knock-out (TAUT KO) mice results in disinhibition of striatal network activity, which can be corrected by taurine supplementation. Modification of GABAA but not glycine receptors (taurine is a ligand for both receptor types) underlies this… CONTINUE READING