GABAA receptor antagonism at the hypoglossal motor nucleus increases genioglossus muscle activity in NREM but not REM sleep.

@article{Morrison2003GABAARA,
  title={GABAA receptor antagonism at the hypoglossal motor nucleus increases genioglossus muscle activity in NREM but not REM sleep.},
  author={Janna L Morrison and Sandeep Sood and Hattie Liu and Eileen Park and Philip Nolan and Richard L Horner},
  journal={The Journal of physiology},
  year={2003},
  volume={548 Pt 2},
  pages={569-83}
}
The pharyngeal muscles, such as the genioglossus (GG) muscle of the tongue, are important for effective lung ventilation since they maintain an open airspace. Rapid-eye-movement (REM) sleep, however, recruits powerful neural mechanisms that can abolish GG activity, even during strong reflex respiratory stimulation by elevated CO2. In vitro studies have demonstrated the presence of GABAA receptors on hypoglossal motoneurons, and these and other data have led to the speculation that GABAA… CONTINUE READING