GABAA receptor alpha1 and alpha6 subunits mediate cell surface anchoring in cultured cells.

@article{Pern2004GABAARA,
  title={GABAA receptor alpha1 and alpha6 subunits mediate cell surface anchoring in cultured cells.},
  author={Macarena Per{\'a}n and Helen Hooper and Sharon L Rayner and F Anne Stephenson and Ramiro Salas},
  journal={Neuroscience letters},
  year={2004},
  volume={364 2},
  pages={
          67-70
        }
}
The clustering and immobility of gamma-aminobutyric acid type A receptors (GABAARs) at discrete and functionally significant domains on the nerve cell surface is an important determinant in the integration of synaptic inputs. To investigate the role that different GABAAR alpha subunit isoforms play in determining receptor mobility, alphaxbeta3gamma2s subunits (where x = subunit isoforms 1-6) were co-transfected into COS 7 and human embryonic kidney (HEK) 293 cells and the surface mobility of… CONTINUE READING