GABAA receptor α1 and α6 subunits mediate cell surface anchoring in cultured cells

@article{Pern2004GABAAR,
  title={GABAA receptor α1 and α6 subunits mediate cell surface anchoring in cultured cells},
  author={Macarena Per{\'a}n and Sharon Bryan and Sharon L Rayner and F Anne Stephenson and Ramiro Salas},
  journal={Neuroscience Letters},
  year={2004},
  volume={364},
  pages={67-70}
}
The clustering and immobility of -aminobutyric acid type A receptors (GABAARs) at discrete and functionally significant domains on the nerve cell surface is an important determinant in the integration of synaptic inputs. To investigate the role that different GABA AR subunit isoforms play in determining receptor mobility, x32s subunits (where x = subunit isoforms 1–6) were co-transfected into COS 7 and human embryonic kidney (HEK) 293 cells and the surface mobility of these recombinant… CONTINUE READING

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