GABAA overactivation potentiates the effects of NMDA blockade during the brain growth spurt in eliciting locomotor hyperactivity in juvenile mice.

@article{OliveiraPinto2015GABAAOP,
  title={GABAA overactivation potentiates the effects of NMDA blockade during the brain growth spurt in eliciting locomotor hyperactivity in juvenile mice.},
  author={Juliana Oliveira-Pinto and Danielle Paes-Branco and Fabiana Cristina-Rodrigues and Thomas E. Krahe and Alex C Manh{\~a}es and Yael Abreu-Villaça and Cl{\'a}udio C. Filgueiras},
  journal={Neurotoxicology and teratology},
  year={2015},
  volume={50},
  pages={
          43-52
        }
}
Both NMDA receptor blockade and GABAA receptor overactivation during the brain growth spurt may contribute to the hyperactivity phenotype reminiscent of attention-deficit/hyperactivity disorder. Here, we evaluated the effects of exposure to MK801 (a NMDA antagonist) and/or to muscimol (a GABAA agonist) during the brain growth spurt on locomotor activity of juvenile Swiss mice. This study was carried out in two separate experiments. In the first experiment, pups received a single i.p. injection… CONTINUE READING

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