GABAA autoreceptors enhance GABA release from human neocortex: towards a mechanism for high-frequency stimulation (HFS) in brain?

@article{Mantovani2009GABAAAE,
  title={GABAA autoreceptors enhance GABA release from human neocortex: towards a mechanism for high-frequency stimulation (HFS) in brain?},
  author={Michela Mantovani and Andr{\'e}as Moser and Carola A Haas and J. Zentner and Thomas J. Feuerstein},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2009},
  volume={380},
  pages={45-58}
}
High-frequency stimulation (HFS) in human neocortical slices induces γ-aminobutyric acid (GABA) release via GABAA receptor (GABAAR) activation. The mechanism of this effect and the localization of these GABAARs were now studied. Fresh human neocortical slices were subjected to HFS (130 Hz) in the presence of veratridine (3 µM). As measured by high-performance liquid chromatography, only GABA but not glutamate outflow was affected by HFS/veratridine stimulation. The evoked GABA overflow was… CONTINUE READING

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