GABAA and GABAB receptors in the nucleus accumbens shell differentially modulate dopamine and acetylcholine receptor-mediated turning behaviour

@article{Akiyama2004GABAAAG,
  title={GABAA and GABAB receptors in the nucleus accumbens shell differentially modulate dopamine and acetylcholine receptor-mediated turning behaviour},
  author={Gaku Akiyama and Hiroko Ikeda and Satoshi Matsuzaki and Michiko Sato and Shoko Moribe and Noriaki Koshikawa and Alexander Rudolf Cools},
  journal={Neuropharmacology},
  year={2004},
  volume={46},
  pages={1082-1088}
}
The ability of GABAA and GABAB receptors in the shell of the nucleus accumbens to modulate distinct types of turning behaviour was investigated in freely moving rats, using the unilateral injection technique. The GABAA receptor agonist muscimol and the GABAA receptor antagonist bicuculline did not produce turning behaviour; the same holds for the GABAB agonist baclofen and the GABAB antagonist 2-hydroxysaclofen. A mixture of the dopamine D1 receptor agonist SKF 38393 and the dopamine D(2/3… Expand
GABA(A) receptors in the nucleus accumbens core modulate turning behavior induced by dopamine receptor stimulation.
TLDR
It is concluded that neither GABA(A) nor GABA(B) receptor stimulation in the core of the nucleus accumbens produces turning behavior, and thatGAB(A), but not GABA( B), receptors in the nucleus Accumbens core may modulate dopamine D1-like/D2-like receptor-mediated pivoting. Expand
GABAA receptors in the mediodorsal thalamus play a crucial role in rat shell-specific acetylcholine-mediated, but not dopamine-mediated, turning behaviour
TLDR
The present study suggests that GABA(A) receptors in the mediodorsal thalamus (mdT) play a limited role in spontaneously occurring locomotor activity and shows that muscimol-sensitive, non-GABA(A%) receptors inThe mdT influence the accumbens-dependent dopaminergic pivoting. Expand
Adrenergic receptors in the nucleus accumbens shell differentially modulate dopamine and acetylcholine receptor-mediated turning behaviour.
TLDR
It is concluded that alpha- and beta-adrenergic agents have an effect on accumbal acetylcholine receptor-mediated circling through a non- adrenergic mechanism and inhibit the dopamine-dependent pivoting of rats. Expand
In vivo neurochemical evidence that stimulation of accumbal GABAA and GABAB receptors each reduce acetylcholine efflux without affecting dopamine efflux in the nucleus accumbens of freely moving rats
Cholinergic neurons in the nucleus accumbens contain GABAA and GABAB receptors that are thought to inhibit neural activity. We analyzed the roles of GABAA and GABAB receptors in regulating accumbalExpand
Somatostatin receptors in the nucleus accumbens modulate dopamine-dependent but not acetylcholine-dependent turning behaviour of rats
TLDR
The results suggest that somatostatin receptors in the nucleus accumbens shell play a modulatory role in rat dopaminergic pivoting, but not in rat cholinergic circling. Expand
Differential role of GABAA and GABAB receptors in two distinct output stations of the rat striatum: studies on the substantia nigra pars reticulata and the globus pallidus
TLDR
It is demonstrated that GABA(A) and GABA(B) receptors in the globus pallidus and the substantina nigra pars reticulata play differential roles in the production of turning behaviour, underlines the notion that the two types of turning, namely pivoting and circling, are valid tools to map out the information flow across the basal ganglia. Expand
Acetylcholine receptor effects on accumbal shell dopamine-mediated turning behaviour in rats
TLDR
The present study shows that muscarinic acetylcholine receptors in the nucleus accumbens shell play an inhibitory role in the production of the Accumbens-dependent, dopamine-mediated pivoting. Expand
Role of orexin receptors in the nucleus accumbens in dopamine-dependent turning behaviour of rats
TLDR
Results suggest that orexin 2 receptors in the nucleus accumbens shell play a modulatory role in rat turning behaviour. Expand
Genetic and pharmacological investigation of α4-containing GABAA receptors in conditioned behaviours influenced by cocaine
α4-subunit containing GABAA receptors (α4-GABAARs) are often found co-assembled with δ-subunits in extrasynaptic locations on nucleus accumbens (NAc) medium spiny neurons (MSNs), were they mediateExpand
N-Methyl-d-aspartate Modulation of Nucleus Accumbens Dopamine Release by Metabotropic Glutamate Receptors: Fast Cyclic Voltammetry Studies in Rat Brain Slices in Vitro.
TLDR
The hypothesis that NMDA receptor activation modulates accumbens dopamine release is tested, and that phencyclidine pretreatment altered this modulation is supported, and the hypothesis that there is no enduring direct effect of PCP at NMDA receptors after this pretreatment procedure is supported. Expand
...
1
2
3
...

References

SHOWING 1-10 OF 57 REFERENCES
GABAA agents injected into the ventral pallidum differentially affect dopaminergic pivoting and cholinergic circling elicited from the shell of the nucleus accumbens
TLDR
It is concluded that the ventromedial portion of the ventral pallidum contains GABA(A) receptors that are crucial for the transmission of information from the shell of the nucleus accumbens via the vental pallidums towards other brain structures; this holds especially for information about shell-specific circling elicited by carbachol. Expand
In vivo modulation of acetylcholine in the nucleus accumbens of freely moving rats: II. Inhibition by γ-aminobutyric acid
TLDR
An inhibitory action of GABA on acetylcholine interneurones in the nucleus accumbens involving both GABAA and GABAB receptor subtypes is demonstrated and a tonic inhibitory GABAergic tone is probably mediated through GAB AA receptors. Expand
Acetylcholine receptor effects on accumbal shell dopamine-mediated turning behaviour in rats
TLDR
The present study shows that muscarinic acetylcholine receptors in the nucleus accumbens shell play an inhibitory role in the production of the Accumbens-dependent, dopamine-mediated pivoting. Expand
Involvement of GABA and cholinergic receptors in the nucleus accumbens on feedback control of somatodendritic dopamine release in the ventral tegmental area
TLDR
The results of this study suggest that terminal DA release in the ACB is under tonic GABA inhibition mediated by GABAA (and possibly GABAB) receptors, and tonic cholinergic excitation mediated by both muscarinic and nicotinic receptors. Expand
Contralateral turning elicited by unilateral stimulation of dopamine D2 and D1 receptors in the nucleus accumbens of rats is due to stimulation of these receptors in the shell, but not the core, of this nucleus
TLDR
It is concluded that dopamine D2 and D1 receptors in the shell, but not the core, of the nucleus accumbens play a critical role in the contralateral turning induced by unilateral injection of dopamine receptor agonists into this nucleus. Expand
Role of AMPA and NMDA receptors in the nucleus accumbens shell in turning behaviour of rats: interaction with dopamine receptors
TLDR
It is concluded that unilateral stimulation of AMPA receptors in the shell of the nucleus accumbens can elicit contraversive pivoting, and that both AMPA and dopamine D(1)/D(2) receptors play a critical role in shell-specific pivoting in contrast to NMDA receptors that at best play only a modulatory role. Expand
Dissimilarities between cholinergic and dopaminergic turning elicited by nucleus accumbens stimulation in freely moving rats.
TLDR
The results demonstrate that there is no functional interaction between the cholinergic and dopaminergic substrates involved, although blockade of the dopamine receptors elicited behavioural deficits that competed with the turning elicited by carbachol. Expand
Dopamine-dependent hyperactivity in the rat following manipulation of GABA mechanisms in the region of the nucleus accumbens
TLDR
The results demonstrate an inhibitory action of GABA and drugs facilitating GABA-ergic transmission on dopamine-dependent hyperactivity in the rat and underlines the potency of the GABA uptake blocking compounds and their possible potential for future clinical use. Expand
Role of dopamine and GABA in the control of motor activity elicited from the rat nucleus accumbens
TLDR
It is concluded that GABAA receptors, together with D1 and D2 receptors, play a major role in modulating the control of motor function by the Acb of rats. Expand
Injections of dopaminergic, cholinergic, serotoninergic and gabaergic drugs into the nucleus accumbens: effects on locomotor activity in the rat
TLDR
It is suggested that both cholinergic and serotoninergic projections may modulate locomotor activity and that such modulation must be at least one inhibitory interneuron away from the dopamine synapse on the locomotor pathway. Expand
...
1
2
3
4
5
...