GABAA and GABAB receptors and the ionic mechanisms mediating their effects on locus coeruleus neurons.

@article{Shefner1991GABAAAG,
  title={GABAA and GABAB receptors and the ionic mechanisms mediating their effects on locus coeruleus neurons.},
  author={S. A. Shefner and S S Osmanovi{\'c}},
  journal={Progress in brain research},
  year={1991},
  volume={88},
  pages={187-95}
}
Anatomical, neurochemical, and electrophysiological studies have provided evidence that gamma-aminobutyric acid (GABA) is an important inhibitory neurotransmitter in the locus coeruleus (LC) nucleus. We have used intracellular recording to study the actions of GABA on putative noradrenergic neurons of the rat LC, in a brain slice preparation. GABA application in the bath, or more locally by micropressure ejection inhibited spontaneous firing and increased the conductance of LC neurons. In… CONTINUE READING

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