GABAA, NMDA and AMPA receptors: a developmentally regulated `ménage à trois'

@article{BenAri1997GABAANA,
  title={GABAA, NMDA and AMPA receptors: a developmentally regulated `m{\'e}nage {\`a} trois'},
  author={Y. Ben-Ari and R. Khazipov and X. Leinekugel and O. Caillard and J. Gaiarsa},
  journal={Trends in Neurosciences},
  year={1997},
  volume={20},
  pages={523-529}
}
The main ionotropic receptors (GABAA, NMDA and AMPA) display a sequential participation in neuronal excitation in the neonatal hippocampus. GABA, the principal inhibitory transmitter in the adult CNS, acts as an excitatory transmitter in early postnatal stage. Glutamatergic synaptic transmission is first purely NMDA-receptor based and lacks functional AMPA receptors. Therefore, initially glutamatergic synapses are 'silent' at resting membrane potential, NMDA channels being blocked by Mg2… Expand
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