GABA uptake-dependent Ca(2+) signaling in developing olfactory bulb astrocytes.

@article{Doengi2009GABAUC,
  title={GABA uptake-dependent Ca(2+) signaling in developing olfactory bulb astrocytes.},
  author={Michael Doengi and Daniela Hirnet and P. G. B. G. M. D. A. S. Coulon and H. Pape and Joachim W. Deitmer and Christian Lohr},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 41},
  pages={17570-5}
}
We studied GABAergic signaling in astrocytes of olfactory bulb slices using confocal Ca(2+) imaging and two-photon Na(+) imaging. GABA evoked Ca(2+) transients in astrocytes that persisted in the presence of GABA(A) and GABA(B) receptor antagonists, but were suppressed by inhibition of GABA uptake by SNAP 5114. Withdrawal of external Ca(2+) blocked GABA-induced Ca(2+) transients, and depletion of Ca(2+) stores with cyclopiazonic acid reduced Ca(2+) transients by approximately 90%. This… CONTINUE READING

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