GABA turnover in the brain of rat lines developed for differential ethanol-induced motor impairment

@article{Hellevuo1989GABATI,
  title={GABA turnover in the brain of rat lines developed for differential ethanol-induced motor impairment},
  author={Kaisa Hellevuo and Kalervo Kiianmaa},
  journal={Pharmacology Biochemistry and Behavior},
  year={1989},
  volume={34},
  pages={905-909}
}
The role of GABAergic neurons in the differential sensitivity to ethanol between the AT (Alcohol Tolerant) and ANT (Alcohol Nontolerant) rat lines developed for low and high degree of motor impairment from ethanol, was studied by comparing the effect of ethanol (2 or 4 g/kg, IP) on GABA turnover in different regions of the brain in these rat lines. GABA turnover was estimated from the accumulation of GABA after inhibition of GABA aminotransferase with aminooxyacetic acid (AOAA, 50 mg/kg, IP… CONTINUE READING
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