GABA systems, benzodiazepines, and substance dependence.

  title={GABA systems, benzodiazepines, and substance dependence.},
  author={Robert J. Malcolm},
  journal={The Journal of clinical psychiatry},
  volume={64 Suppl 3},
Alterations in the gamma-aminobutyric acid (GABA) receptor complex and GABA neurotransmission influence the reinforcing and intoxicating effects of alcohol and benzodiazepines. Chronic modulation of the GABA(A)-benzodiazepine receptor complex plays a major role in central nervous system dysregulation during alcohol abstinence. Withdrawal symptoms stem in part from a decreased GABAergic inhibitory function and an increase in glutamatergic excitatory function. GABA(A) receptors play a role in… CONTINUE READING


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