GABA synthesis mediated by γ-aminobutanal dehydrogenase in Synechocystis sp. PCC6803 with disrupted glutamate and α-ketoglutarate decarboxylase genes.

@article{Kanwal2020GABASM,
  title={GABA synthesis mediated by $\gamma$-aminobutanal dehydrogenase in Synechocystis sp. PCC6803 with disrupted glutamate and $\alpha$-ketoglutarate decarboxylase genes.},
  author={Simab Kanwal and Aran Incharoensakdi},
  journal={Plant science : an international journal of experimental plant biology},
  year={2020},
  volume={290},
  pages={
          110287
        }
}
  • S. Kanwal, A. Incharoensakdi
  • Published 1 January 2020
  • Biology, Chemistry
  • Plant science : an international journal of experimental plant biology

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Overall results suggested that the optimization of carbon and nitrogen sources was effective in enhancing the GABA accumulation in Synechocystis overexpressing the GAD and lacking the functional KGD pathway.

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TLDR
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TLDR
Overall results suggested that optimization of nitrogen source and nitrogenous compounds supplementation was effective for the enhancement of GABA accumulation in Synechocystis.

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TLDR
Root growth of single loss-of-function mutants was more sensitive to salinity than wild-type plants, and this was accompanied by reduced GABA accumulation.

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TLDR
The origin of 4-aminobutyrate (GABA) from glutamate and polyamines, and its subsequent catabolism to succinic semialdehyde and either succinate or 4-hydroxybutyrate is discussed, demonstrating that stress-induced GABA metabolism is strongly linked with respiration.

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