GABA receptors induced in Xenopus oocytes by chick brain mRNA: evaluation of TBPS as a use-dependent channel-blocker.

@article{Renterghem1987GABARI,
  title={GABA receptors induced in Xenopus oocytes by chick brain mRNA: evaluation of TBPS as a use-dependent channel-blocker.},
  author={C van Renterghem and Graeme Bilbe and Stephen J. Moss and Trevor G Smart and Andrew Constanti and David Brown and Eric A. Barnard},
  journal={Brain research},
  year={1987},
  volume={388 1},
  pages={21-31}
}
Sensitivity to GABA was induced in Xenopus laevis oocytes by injection of poly(A)+ mRNA extracted from 19-day chick embryo brain. The effect of the convulsant drug t-butylbicyclophosphorothionate (TBPS) was studied on the responses to bath-applied GABA using voltage-clamp techniques. TBPS reversibly inhibited the GABA-evoked current (IGABA) in a dose-dependent manner; however, the chloride currents evoked by carbachol or serotonin, or the spontaneous chloride fluctuations, were unaffected. The… CONTINUE READING