GABA receptor mechanisms in the central nervous system

@article{Sivilotti1991GABARM,
  title={GABA receptor mechanisms in the central nervous system},
  author={L. Sivilotti and A. Nistri},
  journal={Progress in Neurobiology},
  year={1991},
  volume={36},
  pages={35-92}
}
Neurosteroids differentially modulate fast and slow interictal discharges in the hippocampal CA3 area
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It is demonstrated that potentiation of GABAA receptor‐mediated signaling by THDOC differentially affects slow and fast interictal discharges; these differences may provide insights into how hyperexcitable activity is influenced by neurosteroids. Expand
Essential aminoacid incorporated GABA–phthalimide derivatives: synthesis and anticonvulsant evaluation
A series of novel N-(2-(benzylamino)-1-substituted-2-oxoethyl)-4-(1,3-dioxoisoindolin-2-yl)butanamide derivatives were synthesized unifying the functionalized amino acid unit and GABA–phthalimideExpand
Peripheral GABAB agonists stimulate gastric acid secretion in mice
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Results indicate that, in mice, stimulation of GABAB receptors increases gastric acid secretion through vagal‐ and gastrin‐dependent mechanisms. Expand
The Neuro-endocrinological Role of Microbial Glutamate and GABA Signaling
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The present contribution will attempt to provide a state-of-the art description of the mechanisms by which gut microbiota can affect the gut–brain axis and the multiple cellular and molecular communication circuits (i.e., neural, immune, and humoral). Expand
Redox modulation of homomeric ρ1 GABAC receptors
TLDR
The results demonstrate that, similarly to GABAA receptors and other members of the cys‐loop receptor superfamily, GABAC receptors are subjected to redox modulation. Expand
Presynaptic inhibition by baclofen of miniature EPSCs and IPSCs in substantia gelatinosa neurons of the adult rat spinal dorsal horn
TLDR
Each of glutamatergic and GABAergic nerve terminals in the SG is endowed with the GABAB receptor, the activation of which depresses the release of neurotransmitter from the terminal; this provides a cellular basis for the modulation of pain by baclofen. Expand
Inhibitory control of plateau properties in dorsal horn neurones in the turtle spinal cord in vitro
TLDR
It is suggested that inhibitory regulation of plateau properties plays a role in somatosensory processing in the dorsal horn and the inhibitory control of wind‐up and after‐discharges may be particularly significant in physiological and therapeutic control of central sensitization to pain. Expand
Transient Receptor Potential Vanilloid 4 Inhibits γ-Aminobutyric Acid-Activated Current in Hippocampal Pyramidal Neurons
TLDR
Activation of TRPV4 inhibits GABAA receptor, which may be mediated by activation of AMPK and subsequent down-regulation of PI3K/Akt signaling and activation of PKC signaling, and may account for the neuronal hyperexcitability caused by TRpV4 activation. Expand
The Diversity of Cortical Interneurons
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References

SHOWING 1-10 OF 452 REFERENCES
GABAA receptor function is regulated by phosphorylation in acutely dissociated guinea‐pig hippocampal neurones.
TLDR
The results suggest that the function of the GABAA receptor is maintained by phosphorylation of the receptor or some closely associated regulatory molecule. Expand
On the presynaptic action of baclofen at inhibitory synapses between cultured rat hippocampal neurones.
  • N. Harrison
  • Biology, Medicine
  • The Journal of physiology
  • 1990
TLDR
It is concluded that (‐)baclofen acts presynaptically to reduce the release of GABA and the mechanism by which release is reduced may involve a phacl ofen‐insensitive GABAB receptor. Expand
Phaclofen‐insensitive presynaptic inhibitory action of (±)‐baclofen in neonatal rat motoneurones in vitro
TLDR
It is suggested that bacl ofen depresses excitatory and inhibitory transmission in rat motoneurones by primarily a presynaptic mechanism in reducing the liberation of chemical transmitters from nerve endings via a phaclofen‐insensitive GABAB receptor. Expand
The effect of GABA on the frog optic tectum is sensitive to ammonium and to penicillin.
TLDR
Pharmacological evidence is provided in support of the Cl- dependence of the unusual action of GABA or glycine in facilitating excitatory synaptic transmission in the optic tectum. Expand
gamma‐Aminobutyric acid responses in rat locus coeruleus neurones in vitro: a current‐clamp and voltage‐clamp study.
TLDR
The data suggest that the primary action of GABA on LC neurones is to increase Cl‐ conductance by activation of bicuculline‐sensitive GABAA receptors, a direct action since they persist in low‐Ca2+ and high‐Mg2+ media which block synaptic transmission. Expand
A GABAergic axo-axonic cell in the fascia dentata controls the main excitatory hippocampal pathway
TLDR
A novel type of gamma-aminobutyric acid-ergic inhibitory neurons in the rat fascia dentata that exclusively forms synaptic contacts with the axon initial segments of numerous dentate granule cells is described. Expand
Actions of the GABAB agonist, (−)‐baclofen, on neurones in deep dorsal horn of the rat spinal cord in vitro
TLDR
It is proposed that (−)‐baclofen has more than one mechanism of action in spinal dorsal horn: a postsynaptic action mediated via an increase in potassium conductance and a presynaptic action that is not associated with potassium channels and may be mediated via calcium channels. Expand
Activity-dependent disinhibition. I. Repetitive stimulation reduces IPSP driving force and conductance in the hippocampus in vitro.
TLDR
It is concluded that the decrease in driving force following repetitive stimulation results from an increase in the intracellular Cl- concentration, and that the activity-dependent decrease in gIPSC results from a decrease in presynaptic release rather than from postsynaptic receptor desensitization. Expand
Activity-dependent disinhibition. II. Effects of extracellular potassium, furosemide, and membrane potential on ECl- in hippocampal CA3 neurons.
TLDR
It is concluded that reducing [K+]o caused a hyperpolarizing shift in EGABA and EIPSC by decreasing [Cl-]i, an amount close to that predicted by the Nernst equation for Cl-. Expand
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