GABA receptor mechanisms in the central nervous system

  title={GABA receptor mechanisms in the central nervous system},
  author={Lucia G. Sivilotti and Andrea Nistri},
  journal={Progress in Neurobiology},

Neurosteroids differentially modulate fast and slow interictal discharges in the hippocampal CA3 area

It is demonstrated that potentiation of GABAA receptor‐mediated signaling by THDOC differentially affects slow and fast interictal discharges; these differences may provide insights into how hyperexcitable activity is influenced by neurosteroids.

Essential aminoacid incorporated GABA–phthalimide derivatives: synthesis and anticonvulsant evaluation

The outcomes established the ability of the compounds to suppress the convulsions generated by electrical seizures and the gamma-amino butyric acid level in the different brain regions increased on administration of the active compounds with 4g providing the maximum increment.

Peripheral GABAB agonists stimulate gastric acid secretion in mice

Results indicate that, in mice, stimulation of GABAB receptors increases gastric acid secretion through vagal‐ and gastrin‐dependent mechanisms.

Redox modulation of homomeric ρ1 GABAC receptors

The results demonstrate that, similarly to GABAA receptors and other members of the cys‐loop receptor superfamily, GABAC receptors are subjected to redox modulation.

Inhibitory control of plateau properties in dorsal horn neurones in the turtle spinal cord in vitro

It is suggested that inhibitory regulation of plateau properties plays a role in somatosensory processing in the dorsal horn and the inhibitory control of wind‐up and after‐discharges may be particularly significant in physiological and therapeutic control of central sensitization to pain.

GABA stimulates chemotaxis and chemokinesis of embryonic cortical neurons via calcium-dependent mechanisms

  • T. BeharY‐X. Li J. Barker
  • Biology, Chemistry
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1996
GA-stimulated increases in intracellular Ca2+ may mediate both chemotactic and chemokinetic responses in embryonic cortical cells.

Diazepam biphasically modulates [3H]TBOB binding to the convulsant site of the GABAA receptor complex.

Results indicate that the interaction of the high affinity diazepam site with the [3H]TBOB binding site is totally GABA dependent and that the low affinity effect of diazepAM on [3 H]T BOB binding is at least partially GABA dependent.

Negative Cross Talk between Anionic GABAA and Cationic P2X Ionotropic Receptors of Rat Dorsal Root Ganglion Neurons

Changing the polarity of GABA currents by using intracellular SO42− instead of Cl− significantly reduced the occlusion of ATP currents by GABA, suggesting an important role for Cl− efflux in this phenomenon.



Hippocampal seizures and failure of inhibition

A loss of efficacy of GABA (caused by desensitization or some other process) may be responsible for the failure of inhibition observed during tetanic stimulation, as well as for the subsequent seizures.

Electrophysiological Study of the Neostriatum in Brain Slice Preparation

The slice preparation enables the investigator to manipulate the extracellular milieu in a controlled manner and is well suited for studying the action of putative neurotransmitters and other agents on the electrical activities of neurons and characterizing the relationships between these membrane activities and specific electrolytes.

Biochemical dissection of the γ-aminobutyrate synapse

The molecular actions of two major classes of drugs, the benzodiazepine tranquillizers and the barbiturates, have provided considerable insight into the organization and regulation of the inhibitory synapse at the biochemical level.

GABA and Glycine: Postsynaptic Actions

γ-Aminobutyric acid (GABA) was known to exist in plants and bacteria long before it was discovered to be a major constituent of brain tissue in mammals. Its primary metabolic pathway