GABA potentiation: a logical pharmacological approach for the treatment of acute ischaemic stroke

@article{Green2000GABAPA,
  title={GABA potentiation: a logical pharmacological approach for the treatment of acute ischaemic stroke},
  author={A Richard Green and Atticus H. Hainsworth and David M. Jackson},
  journal={Neuropharmacology},
  year={2000},
  volume={39},
  pages={1483-1494}
}
Coactivation of GABAA and GABAB Receptor Results in Neuroprotection During In Vitro Ischemia
TLDR
Antiepileptic drugs targeting GABAergic transmission can exert neuroprotective effects against ischemia by increasing endogenous GABA levels and via the activation of both GABAA and GABAB receptors.
The Role of Peri-synaptic GABA Receptors After Stroke
TLDR
D dampening tonic GABA inhibition from 3 days poststroke can afford an early and robust improvement in functional recovery after stroke and boosting tonic inhibition early after a stroke can afford significant protection and minimize the extent of neuronal cell loss.
Perisynaptic GABA Receptors The Overzealous Protector
  • A. Clarkson
  • Biology, Psychology
    Advances in pharmacological sciences
  • 2012
TLDR
Substantial evidence suggests that local inhibitory and excitatory currents are altered after stroke and modulation of these networks to enhance excitability during the repair phase can facilitate functional recovery after stroke.
g-Aminobutyric acidA neurotransmission and cerebral ischemia
TLDR
Evidence for the role of g-aminobutyric acid (GABA) neurotransmission in cerebral ischemia-induced neuronal death and how dysfunction of GABA neurotransmission may contribute to neuronal death are presented and how neuronal death can be prevented by GABAergic drugs are discussed.
Protection of Malonate-Induced GABA But Not Dopamine Loss by GABA Transporter Blockade in Rat Striatum
TLDR
GABA transporter blockade during mitochondrial impairment in the striatum provides protection to GABAergic neurons and points to fundamental differences between immature and adult neurons in the downstream involvement of GABA receptors during metabolic insult.
The Gliopeptide ODN, a Ligand for the Benzodiazepine Site of GABAA Receptors, Boosts Functional Recovery after Stroke
TLDR
It is proposed that octadecaneuropeptide (ODN), an endogenous allosteric modulator of the GABAAR synthesized by astrocytes, influences the outcome of ischemic brain tissue and subsequent functional recovery and can be used as a delayed treatment to safely correct cortical excitability and facilitate sensorimotor recovery after stroke.
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